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This Week in The Journal
Opioid drugs and our brain’s endogenous opioids work primarily at mu-type opioid receptors ( R) to dampen pain signals. But because the R is expressed throughout the brain and body, R agonists can cause side effects ranging from constipation to addiction. The related delta-type opioid receptor ( R), in contrast, has more limited expression, but it is found in nociceptive sensory neurons, making...
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Most neurons in the external segment of the globus pallidus (GPe) contribute to the indirect pathway from the dorsal striatum to the output nuclei of the basal ganglia, relaying information from the striatum to the subthalamic nucleus. But 25% of GPe neurons project back to the striatum. These neurons, called arkypallidal neurons, were recently proposed to cancel movements that are in the prepa...
متن کاملThis Week in The Journal
Rather than being distributed evenly throughout the plasma membrane, cellular signaling proteins are concentrated in lipid rafts, which are enriched in sphingolipids and cholesterol. Lipid rafts are particularly dense in neuronal membranes, as are their associated signaling proteins, which direct neuronal differentiation. Palmitoylated proteins aggregate in the detergent-resistant membrane (DRM...
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ژورنال
عنوان ژورنال: IEEE journal of electromagnetics, RF and microwaves in medicine and biology
سال: 2021
ISSN: ['2469-7257', '2469-7249']
DOI: https://doi.org/10.1109/jerm.2021.3125582